Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis.
Identifieur interne : 000518 ( Main/Exploration ); précédent : 000517; suivant : 000519Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis.
Auteurs : Santa Mammana [Italie] ; Placido Bramanti [Italie] ; Emanuela Mazzon [Italie] ; Eugenio Cavalli [Italie] ; Maria Sofia Basile [Italie] ; Paolo Fagone [Italie] ; Maria Cristina Petralia [Italie] ; James Andrew Mccubrey [États-Unis] ; Ferdinando Nicoletti [Italie] ; Katia Mangano [Italie]Source :
- Oncotarget [ 1949-2553 ] ; 2018.
Abstract
The PI3K/AKT/mTOR pathway is an intracellular signalling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Multiple Sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system leading to demyelination and neurodegeneration. In the current study, we have firstly evaluated in silico the involvement of the mTOR network on the generation and progression of MS and on oligodendrocyte function, making use of currently available whole-genome transcriptomic data. Then, the data generated in silico were subjected to an ex-vivo evaluation. To this aim, the involvement of mTOR was validated on a well-known animal model of MS and in vitro on Th17 cells. Our data indicate that there is a significant involvement of the mTOR network in the etiopathogenesis of MS and that Rapamycin treatment may represent a useful therapeutic approach in this clinical setting. On the other hand, our data showed that a significant involvement of the mTOR network could be observed only in the early phases of oligodendrocyte maturation, but not in the maturation process of adult oligodendrocytes and in the process of remyelination following demyelinating injury. Overall, our study suggests that targeting the PI3K/mTOR pathway, although it may not be a useful therapeutic approach to promote remyelination in MS patients, it can be exploited to exert immunomodulation, preventing/delaying relapses, and to treat MS patients in order to slow down the progression of disability.
DOI: 10.18632/oncotarget.23862
PubMed: 29492193
PubMed Central: PMC5823598
Affiliations:
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Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Centro Neurolesi Bonino-Pulejo, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Mazzon, Emanuela" sort="Mazzon, Emanuela" uniqKey="Mazzon E" first="Emanuela" last="Mazzon">Emanuela Mazzon</name><affiliation wicri:level="1"><nlm:affiliation>IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Centro Neurolesi Bonino-Pulejo, Messina</wicri:regionArea><wicri:noRegion>Messina</wicri:noRegion></affiliation></author><author><name sortKey="Cavalli, Eugenio" sort="Cavalli, Eugenio" uniqKey="Cavalli E" first="Eugenio" last="Cavalli">Eugenio Cavalli</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Basile, Maria Sofia" sort="Basile, Maria Sofia" uniqKey="Basile M" first="Maria Sofia" last="Basile">Maria Sofia Basile</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Fagone, Paolo" sort="Fagone, Paolo" uniqKey="Fagone P" first="Paolo" last="Fagone">Paolo Fagone</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Petralia, Maria Cristina" sort="Petralia, Maria Cristina" uniqKey="Petralia M" first="Maria Cristina" last="Petralia">Maria Cristina Petralia</name><affiliation wicri:level="1"><nlm:affiliation>Department of Educational Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Educational Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Mccubrey, James Andrew" sort="Mccubrey, James Andrew" uniqKey="Mccubrey J" first="James Andrew" last="Mccubrey">James Andrew Mccubrey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nicoletti, Ferdinando" sort="Nicoletti, Ferdinando" uniqKey="Nicoletti F" first="Ferdinando" last="Nicoletti">Ferdinando Nicoletti</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author><author><name sortKey="Mangano, Katia" sort="Mangano, Katia" uniqKey="Mangano K" first="Katia" last="Mangano">Katia Mangano</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania</wicri:regionArea><wicri:noRegion>Catania</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The PI3K/AKT/mTOR pathway is an intracellular signalling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Multiple Sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system leading to demyelination and neurodegeneration. In the current study, we have firstly evaluated in silico the involvement of the mTOR network on the generation and progression of MS and on oligodendrocyte function, making use of currently available whole-genome transcriptomic data. Then, the data generated in silico were subjected to an ex-vivo evaluation. To this aim, the involvement of mTOR was validated on a well-known animal model of MS and <i>in vitro</i> on Th17 cells. Our data indicate that there is a significant involvement of the mTOR network in the etiopathogenesis of MS and that Rapamycin treatment may represent a useful therapeutic approach in this clinical setting. On the other hand, our data showed that a significant involvement of the mTOR network could be observed only in the early phases of oligodendrocyte maturation, but not in the maturation process of adult oligodendrocytes and in the process of remyelination following demyelinating injury. Overall, our study suggests that targeting the PI3K/mTOR pathway, although it may not be a useful therapeutic approach to promote remyelination in MS patients, it can be exploited to exert immunomodulation, preventing/delaying relapses, and to treat MS patients in order to slow down the progression of disability.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">29492193</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>9</Issue><PubDate><Year>2018</Year><Month>Feb</Month><Day>02</Day></PubDate></JournalIssue><Title>Oncotarget</Title><ISOAbbreviation>Oncotarget</ISOAbbreviation></Journal><ArticleTitle>Preclinical evaluation of the PI3K/Akt/mTOR pathway in animal models of multiple sclerosis.</ArticleTitle><Pagination><MedlinePgn>8263-8277</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.18632/oncotarget.23862</ELocationID><Abstract><AbstractText>The PI3K/AKT/mTOR pathway is an intracellular signalling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Multiple Sclerosis (MS) is one of the most common chronic inflammatory diseases of the central nervous system leading to demyelination and neurodegeneration. In the current study, we have firstly evaluated in silico the involvement of the mTOR network on the generation and progression of MS and on oligodendrocyte function, making use of currently available whole-genome transcriptomic data. Then, the data generated in silico were subjected to an ex-vivo evaluation. To this aim, the involvement of mTOR was validated on a well-known animal model of MS and <i>in vitro</i> on Th17 cells. Our data indicate that there is a significant involvement of the mTOR network in the etiopathogenesis of MS and that Rapamycin treatment may represent a useful therapeutic approach in this clinical setting. On the other hand, our data showed that a significant involvement of the mTOR network could be observed only in the early phases of oligodendrocyte maturation, but not in the maturation process of adult oligodendrocytes and in the process of remyelination following demyelinating injury. Overall, our study suggests that targeting the PI3K/mTOR pathway, although it may not be a useful therapeutic approach to promote remyelination in MS patients, it can be exploited to exert immunomodulation, preventing/delaying relapses, and to treat MS patients in order to slow down the progression of disability.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mammana</LastName><ForeName>Santa</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bramanti</LastName><ForeName>Placido</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazzon</LastName><ForeName>Emanuela</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavalli</LastName><ForeName>Eugenio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basile</LastName><ForeName>Maria Sofia</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fagone</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petralia</LastName><ForeName>Maria Cristina</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Department of Educational Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCubrey</LastName><ForeName>James Andrew</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Brody School of Medicine, East Carolina University, Greenville, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicoletti</LastName><ForeName>Ferdinando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mangano</LastName><ForeName>Katia</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Oncotarget</MedlineTA><NlmUniqueID>101532965</NlmUniqueID><ISSNLinking>1949-2553</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">autoimmunity</Keyword><Keyword MajorTopicYN="N">bioinformatics</Keyword><Keyword MajorTopicYN="N">mTOR</Keyword><Keyword MajorTopicYN="N">multiple sclerosis</Keyword></KeywordList><CoiStatement>CONFLICTS OF INTEREST The authors declare no competing financial interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>09</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>11</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>3</Month><Day>2</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29492193</ArticleId><ArticleId IdType="doi">10.18632/oncotarget.23862</ArticleId><ArticleId IdType="pii">23862</ArticleId><ArticleId IdType="pmc">PMC5823598</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Neurosci. 2008 May 21;28(21):5422-32</Citation><ArticleIdList><ArticleId IdType="pubmed">18495876</ArticleId></ArticleIdList></Reference><Reference><Citation>Brain. 2013 Jun;136(Pt 6):1799-815</Citation><ArticleIdList><ArticleId IdType="pubmed">23687122</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2017 Aug;65:5-15</Citation><ArticleIdList><ArticleId IdType="pubmed">28712664</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2012 Apr 20;12(5):325-38</Citation><ArticleIdList><ArticleId IdType="pubmed">22517423</ArticleId></ArticleIdList></Reference><Reference><Citation>World J Transplant. 2016 Mar 24;6(1):183-92</Citation><ArticleIdList><ArticleId IdType="pubmed">27011916</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neuroimmunol. 2010 Mar 30;220(1-2):52-63</Citation><ArticleIdList><ArticleId IdType="pubmed">20149931</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2017 Aug;65:36-58</Citation><ArticleIdList><ArticleId IdType="pubmed">28549531</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2017 May;64:39-48</Citation><ArticleIdList><ArticleId IdType="pubmed">28189457</ArticleId></ArticleIdList></Reference><Reference><Citation>J Autoimmun. 2009 Sep;33(2):135-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19625166</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2016 Jul 13;7:CD011272</Citation><ArticleIdList><ArticleId IdType="pubmed">27409709</ArticleId></ArticleIdList></Reference><Reference><Citation>J Health Econ. 2003 Mar;22(2):151-85</Citation><ArticleIdList><ArticleId IdType="pubmed">12606142</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Exp Immunol. 2009 Jan;155(1):28-34</Citation><ArticleIdList><ArticleId IdType="pubmed">19076826</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Rev Immunol. 2015 Jan;34(1):50-66</Citation><ArticleIdList><ArticleId IdType="pubmed">25019278</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Drug Targets. 2015;16(10):1107-32</Citation><ArticleIdList><ArticleId IdType="pubmed">25850623</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neuroimmunol. 2012 Feb 29;243(1-2):43-51</Citation><ArticleIdList><ArticleId IdType="pubmed">22264993</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Anticancer Ther. 2014 Jan;14(1):9-21</Citation><ArticleIdList><ArticleId IdType="pubmed">24313573</ArticleId></ArticleIdList></Reference><Reference><Citation>Allergol Int. 2008 Jun;57(2):115-20</Citation><ArticleIdList><ArticleId IdType="pubmed">18427164</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Rev Neurobiol. 2007;79:589-620</Citation><ArticleIdList><ArticleId IdType="pubmed">17531860</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Biol Regul. 2015 Jan;57:10-6</Citation><ArticleIdList><ArticleId IdType="pubmed">25482988</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2010 Aug 25;30(34):11388-97</Citation><ArticleIdList><ArticleId IdType="pubmed">20739560</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2004 Aug;3(8):673-83</Citation><ArticleIdList><ArticleId IdType="pubmed">15286734</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2008 Jul 9;28(28):7174-83</Citation><ArticleIdList><ArticleId IdType="pubmed">18614687</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2009 May 13;29(19):6367-78</Citation><ArticleIdList><ArticleId IdType="pubmed">19439614</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2010 Sep;1803(9):991-1002</Citation><ArticleIdList><ArticleId IdType="pubmed">20399811</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2007 Aug 9;448(7154):645-6</Citation><ArticleIdList><ArticleId IdType="pubmed">17687303</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2012 Oct 09;3:312</Citation><ArticleIdList><ArticleId IdType="pubmed">23087689</ArticleId></ArticleIdList></Reference><Reference><Citation>Aging (Albany NY). 2011 Mar;3(3):192-222</Citation><ArticleIdList><ArticleId IdType="pubmed">21422497</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Clin Pharmacol. 2010 Dec;70(6):784-93</Citation><ArticleIdList><ArticleId IdType="pubmed">21175433</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2010 Jun;1(2):89-103</Citation><ArticleIdList><ArticleId IdType="pubmed">20671809</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2015 Jan 7;35(1):4-20</Citation><ArticleIdList><ArticleId IdType="pubmed">25568099</ArticleId></ArticleIdList></Reference><Reference><Citation>J Neurosci. 2010 Jun 30;30(26):8953-64</Citation><ArticleIdList><ArticleId IdType="pubmed">20592216</ArticleId></ArticleIdList></Reference><Reference><Citation>Fitoterapia. 2017 Jan;116:77-84</Citation><ArticleIdList><ArticleId IdType="pubmed">27890794</ArticleId></ArticleIdList></Reference><Reference><Citation>Drug Discov Today. 2011 Aug;16(15-16):715-21</Citation><ArticleIdList><ArticleId IdType="pubmed">21624501</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2011 Mar;2(3):135-64</Citation><ArticleIdList><ArticleId IdType="pubmed">21411864</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2017;23 (20):3005-3014</Citation><ArticleIdList><ArticleId IdType="pubmed">28078989</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncotarget. 2012 Oct;3(10 ):1068-111</Citation><ArticleIdList><ArticleId IdType="pubmed">23085539</ArticleId></ArticleIdList></Reference><Reference><Citation>Oncogene. 2007 Mar 22;26(13):1932-40</Citation><ArticleIdList><ArticleId IdType="pubmed">17001314</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><country name="Italie"><noRegion><name sortKey="Mammana, Santa" sort="Mammana, Santa" uniqKey="Mammana S" first="Santa" last="Mammana">Santa Mammana</name></noRegion><name sortKey="Basile, Maria Sofia" sort="Basile, Maria Sofia" uniqKey="Basile M" first="Maria Sofia" last="Basile">Maria Sofia Basile</name><name sortKey="Bramanti, Placido" sort="Bramanti, Placido" uniqKey="Bramanti P" first="Placido" last="Bramanti">Placido Bramanti</name><name sortKey="Cavalli, Eugenio" sort="Cavalli, Eugenio" uniqKey="Cavalli E" first="Eugenio" last="Cavalli">Eugenio Cavalli</name><name sortKey="Fagone, Paolo" sort="Fagone, Paolo" uniqKey="Fagone P" first="Paolo" last="Fagone">Paolo Fagone</name><name sortKey="Mangano, Katia" sort="Mangano, Katia" uniqKey="Mangano K" first="Katia" last="Mangano">Katia Mangano</name><name sortKey="Mazzon, Emanuela" sort="Mazzon, Emanuela" uniqKey="Mazzon E" first="Emanuela" last="Mazzon">Emanuela Mazzon</name><name sortKey="Nicoletti, Ferdinando" sort="Nicoletti, Ferdinando" uniqKey="Nicoletti F" first="Ferdinando" last="Nicoletti">Ferdinando Nicoletti</name><name sortKey="Petralia, Maria Cristina" sort="Petralia, Maria Cristina" uniqKey="Petralia M" first="Maria Cristina" last="Petralia">Maria Cristina Petralia</name></country><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Mccubrey, James Andrew" sort="Mccubrey, James Andrew" uniqKey="Mccubrey J" first="James Andrew" last="Mccubrey">James Andrew Mccubrey</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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